Understanding biomolecules through chemistry.

Publications

Dillon T. Flood, Kyle W. Knouse, Julien C. Vantourout, Brittany B. Sanchez, Emily J. Sturgell, Jason S. Chen, Phil S. Baran, Philip E. Dawson, Synthetic Elaboration of Native DNA by RASS (SENDR), Chemrxiv, preprint

 Dillon T. Flood, Jordi C.J. Hintzen, Chenxi Lu, Philip A. Cistrone, Jason Chen, Takanori Otomo, Philip E. Dawson. 2020, Chemrxiv, preprint

Philip A. Cistrone, Anouk Dirksen, Sampat Ingale and Philip E. Dawson: Scandium(III) Triflate as a Lewis Acid Catalyst of Oxime Ligation, Aust. https://doi.org/10.1071/CH20042

Flood, D.T.; Kingston, C.; Vantourout, J.C.; Dawson, P.E.; Baran, P.S.; DNA Encoded Libraries: A Visitor’s Guide, Isr. J. Chem. 60, 1-14

D. T. Flood, X. Zhang, X. Fu, Z. Zhao, S. Asai, B. B. Sanchez, E. J. Sturgell, J. C. Vantourout, P. Richardson, M. E. Flanagan, D. W. Piotrowski, D. K. Kölmel, J. Wan, M.-H. Tsai, J. S. Chen, P. S. Baran, P. E. Dawson, Angew. Chem. Int. Ed. 202059, 7377. https://doi.org/10.1002/anie.201915493

Won Y, Jeon H, Pagar AD, Patil MD, Nadarajan SP, Flood DT, Dawson PE, Yun H.* In vivo Biosynthesis of Tyrosine Analogs and their Concurrent Incorporation in a Residue-specific Manner for Enzyme Engineering, Chem. Commun. 2019, 55, 15133-15136

Reichart, Timothy; Leaman, Daniel; Sands, Daniel; Zwick, Michael; Dawson, Philip (2019): The Conserved Positive Charge in the Transmembrane Domain of HIV Gp41 Contributes to Its Intrinsic Preference for Trimerization. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.9992369.v1

Flood DT, Asai S, Zhang X, Wang J, Yoon L, Adams ZC, Dillingham BC, Sanchez BB, Vantourout JC, Flanagan ME, Piotrowski DW, Richardson P, Green SA, Shenvi RA, Chen JS, Baran PS, Dawson PE. Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support. J Am Chem Soc. 2019, 141(25):9998-10006. 10.1021/jacs.9b03774

Weidmann J, Schnolzer M, Dawson PE, Hoheisel JD. Copying Life: Synthesis of an Enzymatically Active Mirror-Image DNA-Ligase Made of D-Amino Acids. Cell Chem Biol. 2019, 26(5):645-51. 10.1016/j.chembiol.2019.02.008

Cistrone PA, Bird MJ, Flood DT, Silvestri AP, Hintzen JCJ, Thompson DA, Dawson PE. Native Chemical Ligation of Peptides and Proteins. Curr Protoc Chem Biol. 2019, 11(1):e61. 10.1002/cpch.61

Palomo V, Cistrone PA, Zhan N, Palui G, Mattoussi H, Dawson PE. Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins. Bioconjug Chem. 2018, 29(9), 3144-53. 10.1021/acs.bioconjchem.8b00477

Flood DT, Hintzen JCJ, Bird MJ, Cistrone PA, Chen JS, Dawson PE. Leveraging the Knorr Pyrazole Synthesis for the Facile Generation of Thioester Surrogates for use in NCL. Angew Chem Int Ed Engl. 2018, Epub ahead of print. 10.1002/anie.201805191

Flood DT, Yan NL, Dawson PE. Post-Translational Backbone Engineering through Selenomethionine-Mediated Incorporation of Freidinger Lactams. Angew Chem Int Ed Engl. 2018, Epub ahead of print. 10.1002/anie.201804885

Bird MJ, Silvestri AP, Dawson PE. Expedient on-resin synthesis of peptidic benzimidazoles. Bioorg Med Chem Lett 2018, Epub ahead of print. https://doi.org/10.1016/j.bmcl.2018.04.062

Lee TC, Moran CR, Cistrone PA, Dawson PE, Deniz AA. Site-Specific Three-Color Labeling of α-Synuclein via Conjugation to Uniquely Reactive Cysteines during Assembly by Native Chemical Ligation. Cell Chem Biol 2018, 25(6), 797-801. https://doi.org/10.1016/j.chembiol.2018.03.009

Cistrone PA, Silvestri AP, Hintzen JCJ, Dawson PE. Rigid Peptide Macrocycles via On-Resin Glaser Stapling. Chembiochem 2018, Epub ahead of print. http://dx.doi.org/10.1002/cbic.201800121

Liew SK, Holownia A, Diaz DB, Cistrone PA, Dawson PE, Yudin AK. Borylated oximes: versatile building blocks for organic synthesis. Chem Commun (Camb) 2017, 53(81), 11237-40. 10.1039/c7cc06579e

Silvestri AP, Cistrone PA, Dawson PE. Adapting the Glaser Reaction for Bioconjugation: Robust Access to Structurally Simple, Rigid Linkers. Angew Chem Int Ed Engl. 2017, 56(35), 10438-42. 10.1002/anie.201705065

Breger JC, Muttenthaler M, Delehanty JB, Thompson DA, Oh E, Susumu K, Deschamps JR, Anderson GP, Field LD, Walper SA, Dawson PE, Medintz IL. Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery. Nanoscale 2017, 9(29), 10447-64. 10.1039/C7NR03362A

Silvestri AP, Dawson PE. Base-catalyzed diastereoselective trimerization of trifluoroacetone. Organic & Biomolecular Chemistry 2017, 15(24), 5131-4. 10.1039/c7ob01094j

Adhikary R, Tan YX, Liu J, Zimmermann J, Holcomb M, Yvellez C, Dawson PE, Romesberg FE. Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid. Biochemistry 2017, 56(22), 2787-93. 10.1021/acs.biochem.7b00255

Nag OK, Stewart MH, Deschamps JR, Susumu K, Oh E, Tsytsarev V, Tang Q, Efros AL, Vaxenburg R, Black BJ, Chen Y, O’Shaughnessy TJ, North SH, Field LD, Dawson PE, Pancrazio JJ, Medintz IL, Chen Y, Erzurumlu RS, Huston AL, Delehanty JB. Quantum Dot-Peptide-Fullerene Bioconjugates for Visualization of in Vitro and in Vivo Cellular Membrane Potential. ACS Nano 2017, 11(6), 5598-613. 10.1021/acsnano.7b00954

Algar WR, Khachatrian A, Melinger JS, Huston AL, Stewart MH, Susumu K, Blanco-Canosa JB, Oh E, Dawson PE, Medintz IL. Concurrent Modulation of Quantum Dot Photoluminescence Using a Combination of Charge Transfer and Förster Resonance Energy Transfer: Competitive Quenching and Multiplexed Biosensing Modality. Journal of the American Chemical Society 2017, 139(1), 363-72. doi: 10.1021/jacs.6b11042

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Matthews M, He L, Horning B, Olson E, Correia B, Yates, J, Dawson P, Cravatt B. Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nature Chemistry 2016, published online October 2016. doi: 10.1038/nchem.2645

Getz T, Qin J, Medintz IL, Delehanty JB, Susumu K, Dawson PE, Dawson G. Quantom dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells. Journal of Neurochemistry 2016, 139(5), 872-85. doi: 10.1111/jnc.13841

Palomo V, Diaz SA, Stewart MH, Susumu K, Medintz IL, Dawson PE. 3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase. ACS Nano 2016, 10(6), 6090-9. doi: 10.1021/acsnano.6b01682

Olson EJ, Lechtenberg BC, Zhao C, Rubio de la Torre E, Lamberto I, Riedl SJ, Dawson PE, Pasquale EB. Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor to Achieve High Plasma Stability. ACS Medicinal Chemistry Letters 2016, 7(9), 841-6. doi: 10.1021/acsmedchemlett.6b00132

Agten SM, Dawson PE, Hackeng TM. Oxime conjugation in Protein Chemistry: from Carbonyl Incorporation to Nucleophilic Catalysis. Journal of Peptide Science 2016, 22(5), 271-9. doi: 10.1002/psc.2874/epdf

Thompson D, Ng R, Dawson P. Arginine Selective Reagents for Ligation to Peptides and Proteins. Journal of Peptide Science 2016, online 1-9. doi: 10.1002/psc.2867/epdf

Cistrone P and Dawson P. Click-Based Libraries of SFTI-1 Peptides: New Methods Using Reversed-Phase Silica. ACS Combinatorial Science 2016, 18(3), 139-43. doi: 10.1021/acscombsci.5b00195

Reichart TM, Baksh MM, Rhee JK, Fiedler JD, Sligar SG, Finn MG, Zwich MB, Dawson PE. Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding. Angew Chem Int Ed Engl. 2016 Jan 22. doi: 10.1002/anie.201508421

Weidmann J, Dimitrijević E, Hoheisel JD, Dawson PE. Boc-SPPS: Compatible Linker for the Synthesis of Peptide o-Aminoanilides. Organic Letters 2016, 18(2), 164-7. doi: 10.1021/acs.orglett.5b03111

Olea C Jr, Weidmann J, Dawson PE, Joyce GF. An L-RNA Aptamer That Binds and Inhibits Ribonuclease. Chemistry & Biology 2015, 22(11), 1437-41. doi: 10.1016/j.chembiol.2015.09.017

Zhang H, Sturchler E, Zhu J, Gutierrez AN, Cistrone P, Xie J, He L, Yea K, Jones T, Turn R, DiStefano P, Griffin PR, Dawson P, McDonald P, Lerner R. Autocrine Selection of a GLP-1R G-protein Biased Agonist with Potent Antidiabetic Effects. Nature Communications 2015, 6, 8918. doi: 10.1038/ncomms9918
Zhan N, Palui G, Kapur A, Palomo V, Dawson PE, Mattoussi H. Controlling the Architecture, Coordination, and Reactivity of Nanoparticle Coating Utilizing an Amino Acid Central Scaffold. Journal of the American Chemical Society 2015, 137(51), 16084-97. doi: 10.1021/jacs.5b10359
Gemmill KB, Diaz SA, Blanco-Canosa JB, Deschamps JR, Pons T, Liu H-W, Deniz A, Melinger J, Oh E, Susumu K, Stewart MH, Hastman Jr. DA, North SH, Delehanty JB, Dawson PE. Examining the Polyproline Nanoscopic Ruler in the Context of Quantum Dots. Chemistry of Materials 2015, 27(18), 6222-37. doi: 10.1021/acs.chemmater.5b03181
Adhikary RZimmermann JDawson PERomesberg FE. Temperature Dependence of CN and SCN IR Absorptions Facilitates Their Interpretation and Use as Probes of Proteins. Analytical Chemistry 2015, 17;87(22), 11561-7. doi: 10.1021/acs.analchem.5b03437
Wang W, Kapur A, Ji X, Safi M, Palui G, Palomo V, Dawson PE, Mattoussi H. Photoligation of an amphiphilic polymer with mixed coordination provides compact and reactive quantum dots. Journal of the American Chemical Society 2015, 137(16), 5438-51. doi: 10.1021/jacs.5b00671
Walters R, Medintz IL, Delehanty JB, Stewart MH, Susumu K, Huston AL, Dawson PE, Dawson G. The Role of Negative Charge in the Delivery of Quantum Dots to Neurons. ASN Neuro 2015, 7(4). doi: 10.1177/1759091415592389
Muttenthaler M, Albericio F, Dawson PE. Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis. Nature Protocols 2015, 10(7), 1067-83. doi: 10.1038/nprot.2015.061
Kong L, Kadam RU, Giang E, Ruwona TB, Nieusma T, Culhane JC, Stanfield RL, Dawson PE, Wilson IA, Law M. Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526. Journal of Molecular Biology 2015, 427(16), 2617-28. doi: 10.1016/j.jmb.2015.06.012
Blanco-Canosa JB, Nardone B, Albericio F, Dawson PE. Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors. Journal of the American Chemical Society 2015, 137(22):7197-209. doi: 10.1021/jacs.5b03504
Assem N, Ferreira DJ, Wolan DW, Dawson PE. Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling. Angew Chem Int Ed Engl. 2015, 54(30), 8665-8. doi: 10.1002/anie.201502607
Aldeek F, Hawkins D, Palomo V, Safi M, Palui G, Dawson PE, Alabugin I, Mattoussi H. UV and Sunlight Driven Photoligation of Quantum Dots: Understanding the Photochemical Transformation of the Ligands. Journal of the American Chemical Society 2015, 5;137(7), 2704-14. doi: 10.1021/ja512802x
Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson G. Delivery and Tracking of Quantum Dot Peptide Bioconjugates in an Intact Developing Avian Brain. ACS Chemical Neuroscience 2015, 6(3), 494-504. doi: 10.1021/acschemneuro.5b00022
Blanco-Canosa JB, Wu M. Susumu K, Petryayeva E, Jennings TL, Dawson PE, Algar WR, Medintz IL. Recent progress in the bioconjugation of quantum dots. Coordination Chemistry Reviews 2014, 263-264, 101-137. S0010854513001860
Lamberto I, Lechtenberg BC, Olson EJ, Mace PD, Dawson PE, Riedl SJ, Pasquale EB. Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor. ACS Chemical Biology 2014, Oct 14. 19;9(12), 2787-95. doi: 10.1021/cb500677x
Adhikary R, Zimmermann J, Liu J, Forrest RP, Janicki TD, Dawson PE, Corcelli SA, Romesberg FE. Evidence of an unusual N-H···N Hydrogen Bond in Proteins. Journal of the American Chemical Society 2014, 136(39), 13474-7. doi: 10.1021/ja503107h
Scott AM, Algar WR, Stewart MH, Trammell SA, Blanco-Canosa JB Dawson PE, Deschamps JR, Goswami R, Oh E, Huston AL, Medintz IL. Probing the quenching of quantum dot photoluminescence by peptide-labeled ruthenium(II) complexes. Journal of Physical Chemistry C 2014, 118(17), 9239-50. doi: 10.1021/jp501039w
Adhikary R, Zimmermann J, Dawson PE, Romesberg FE. IR Probes of Protein Microenvironments: Utility and Potential for Perturbation. ChemPhysChem 2014, 15(5), 849-853. doi: 10.1002/cphc.201400017
Koehbach J, O’Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Goransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences 2013, 110(52), 21183-8. doi: 10.1073/pnas.1311183110
Wendeler M, Grinberg L, Wang X, Dawson PE, Baca MI. Enhanced Catalysis of Oxime-Based Bioconjugations by Substituted Anilines. Bioconjugate Chemistry 2014, 25(1), 93-101. doi: 10.1021/bc400380f
Algar WR, Blanco-Canosa JB, Manthe RL, Susumu K, Stewart MH, Dawson PE, Medintz IL. Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates.  Methods in Molecular Biology 2013,1025, 47-73. doi: 10.1007/978-1-62703-462-3_5
Stewart MH, Huston AL, Scott AM, Oh E, Algar WR, Deschamps JR, Susumu K, Jain V, Prasuhn DE, Blanco-Canosa J, Dawson PE, Medintz IL.  Competition between Förster resonance energy transfer and electron transfer in stoichiometrically assembled semiconductor quantum dot-fullerene conjugates. ACS Nano 2013, 7(10), 9489-505. doi: 10.1021/nn403872x
Bradburne CE, Delehanty JB, Boeneman K, Mei BC, Mattoussi H, Susumu K, Blanco-Conosa J, Dawson PE, Medintz IL. Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type and direct comparison to organic fluorophoresBioconjugate Chemistry 2013, 24(9), 1570-83. doi: 10.1021/bc4001917
Adhikary R, Zimmermann J, Liu J, Dawson PE, Romesberg FE. Experimental characterization of electrostatic and conformational heterogeneity in an SH3 domain. Journal of Physical Chemistry B 2013, 117(42), 13082-9. doi: 10.1021/jp402772x
Delehanty JB, Blanco-Canosa JB, Bradburne CE, Susumu K, Stewart MH, Prasuhn DE, Dawson PE, Medintz IL. Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides. Chemistry Communications 2013, 49(72), 7878-80. doi: 10.1039/c3cc42781a
Gemmill KB, Muttenthaler M, Delehanty JB, Stewart MH, Susumu K, Dawson PE, Medintz IL. Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots. Analytical and Bioanalytical Chemistry 2013, 405(19), 6145-54. doi: 10.1007/s00216-013-6982-2
Boeneman K, Delehanty JB, Blanco-Canosa JB, Susumu K, Stewart MH, Oh E, Huston AL, Dawson G, Ingale S, Walters R, Domowicz M, Deschamps JR, Algar WR, Dimaggio S, Manono J, Spillmann CM, Thompson D, Jennings TL, Dawson PE, Medintz IL. Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials. ACS Nano 2013, 7(5), 3778-96. doi: 10.1021/nn400702r
Walters R, Kraig RP, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Dawson PE, Dawson G. Nanoparticle targeting to neurons in a rat hippocampal slice culture model. American Society for Neurochemistry 2012, 4(6), 383-92. doi:10.1042/an20120042
Algar WR, Malonoski A, Deschamps JR, Blanco-Canosa JB, Susumu K, Stewart MH, Johnson BJ, Dawson PE, Medintz IL. Proteolytic activity at quantum dot-conjugates: kinetic analysis reveals enhanced enzyme activity and localized interfacial “hopping”. ACS Nano Letters 2012, 12(7), 3793-802. doi:10.1021/nl301727k
Yu W, Dawson PE, Zimmermann J, Romesberg FE. Carbon-deuterium bonds as probes of protein thermal unfolding, Journal of Physical Chemistry B 2012, 116(22), 6397-403. doi:10.1021/jp303521t
Stewart MH, Huston AL, Scott AM, Efros AL, Melinger JS, Gemmill KB, Trammell SA, Blanco-Canosa JB, Dawson PE, Medintz IL. Complex Förster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assembly. ACS Nano Letters 2012, 6(6), 5330-47. doi:10.1021/nn301177h
Wu Z, Chen K, Yildiz I, Dirksen A, Fischer R, Dawson PE, Steinmetz NF. Development of viral nanoparticles for efficient intracellular delivery. Nanoscale 2012, 4(11), 3567-76. doi:10.1039/c2nr30366c
Algar WR, Wegner D, Huston AL, Blanco-Canosa JB, Stewart MH, Armstrong A, Dawson PE, Hildebrandt N, Medintz IL. Quantum dots as simultaneous acceptors and donors in time-gated Förster resonance energy transfer relays: characterization and biosensing. Journal of American Chemical Society 2012, 134(3), 1876-91. doi:10.1021/ja210162f
Buckhout-White S, Ancona M, Oh E, Deschamps JR, Stewart MH, Blanco-Canosa JB, Dawson PE. Multimodal characterization of a linear DNA-based nanostructure. ACS Nano Letters 2012, 6(2), 1026-43. doi:10.1021/nn204680r
Dawson PE. Native chemical ligation combined with desulfurization and deselenization: A general strategy for chemical protein synthesis. Israel Journal of Chemistry 2011, 51(8-9), 862-7. doi:10.1002/ijch.201100128
Morgner F, Stufler S, Geissler D, Medintz IL, Algar WR, Susumu, K, Stewart MH, Blanco-Canosa JB, Dawson PE, Hildebrandt N. Terbium to quantum dot FRET bioconjugates for clinical diagnostics: influence of human plasma on optical and assembly properties. Sensors (Basel) 2011, 11(10), 9667-84. doi:10.3390/s111009667
Zimmermann J, Thielges MC, Seo YJ, Dawson PE, Romesberg FE. Cyano groups as probes of protein microenvironments and dynamics. Angew Chem Int Ed Engl. 2011, 50(36), 8333-37. doi:10.1002/anie.201101016
Algar WR, Prasuhn DE, Stewart MH, Jennings TL, Blanco-Canosa JB, Dawson PE, Medintz IL. The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry. Bioconjugate Chemistry 2011, 22(5), 825-58. doi:10.1021/bc200065z
Oh E, Delehanty JB, Sapsford KE, Susumu K, Goswami R, Blanco-Canosa JB, Dawson PE, Granek J, Shoff M, Zhang Q, Goering PL, Huston A, Medintz IL. Cellular uptake and fate of pegylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. ACS Nano Letters 2011, 5(8), 6434-48. doi:10.1021/nn201624c
Ingale S, Dawson PE. On resin side-chain cyclization of complex peptides using CuAAC. Organic Letters 2011, 13(11), 2822-5. doi:10.1021/ol200775h
Zimmermann J, Thielges MC, Yu W, Dawson PE, Romesberg FE. Carbon-deuterium bonds as site-specific and nonperturbative probes for time-resolved studies of protein dynamics and folding. Journal of Physical Chemistry Letters 2011, 2(5), 412-16. doi:10.1021/jz200012h
Delehanty JB, Bradburne CE, Susumu K, Boeneman K, Mei BC, Farrell D, Blanco-Canosa JB, Dawson PE, Mattoussi H, Medintz IL. Spatiotemporal multicolor labeling of individual cells using peptide-functionalized quantum dots and mixed delivery techniques. Journal of the American Chemical Society 2011, 133(27), 10482-9. doi:10.1021/ja200555z
Susumu K, Oh E, Delehanty JB, Blanco-Canosa JB, Johnson BJ, Jain V, Hervey WJ, Algar WR, Boeneman K, Dawson PE, Medintz IL. Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles. Journal of the American Chemical Society 2011, 133(24), 9480-96. doi:10.1021/ja201919s
Venter PA, Dirksen A, Thomas D, Manchester M, Dawson PE, Schneemann A. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies. Biomacromolecules 2011, 12(6), 2293-301. doi:10.1021/bm200369e
Sapsford KE, Granek J, Deschamps JR, Boeneman K, Blanco-Canosa JB, Dawson PE, Susumu K, Stewart MH, Medintz IL. Monitoring botulinum neurotoxin a activity with Peptide-functionalized quantum dot resonance energy transfer sensors. ACS Nano 2011, 5(4):2687-99. doi:10.1021/nn102997b
Boeneman K, Prasuhn DE, Blanco-Canosa JB, Dawson PE, Melinger JS, Ancona M, Stewart MH, Susumu K, Huston A, Medintz IL. Self-assembled quantum dot-sensitized multivalent DNA photonic wires. Journal of the American Chemical Society 2010,132(51),18177-90. doi:10.1021/ja106465x
Ingale S, Gach JS, Zwick MB, Dawson PE. Synthesis and analysis of the membrane proximal external region epitopes of HIV-1. Journal of Peptide Science 2010, 16(12), 716-22. doi:10.1002/psc.1325
Boeneman K, Deschamps JR, Buckhout-White S, Prasuhn DE, Blanco-Canosa JB, Dawson PE, Stewart MH, Susumu K, Goldman ER, Ancona M, Medintz IL. Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture. ACS Nano 2010, 4(12), 7253-66. doi:10.1021/nn1021346
Prasuhn DE, Feltz A, Blanco-Canosa JB, Susumu K, Stewart MH, Mei BC, Yakovlev AV, Loukov C, Mallet JM, Oheim M, Dawson PE, Medintz IL. Quantum dot peptide biosensors for monitoring caspase 3 proteolysis and calcium ions. ACS Nano 2010, 4(9), 5487-97. doi:10.1021/nn1016132
Metanis N, Keinan E, Dawson PE. Traceless ligation of cysteine peptides using selective deselenization. Angew Chem Int Ed Engl. 2010, 49(39), 7049-53. doi:10.1002/anie.201001900
Medintz IL, Stewart MH, Trammell SA, Susumu K, Delehanty JB, Mei BC, Melinger JS, Blanco-Canosa JB, Dawson PE, Mattoussi H. Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nature Materials 2010, 9(8), 676-84. doi:10.1038/nmat2811
Blanco-Canosa JB, Medintz IL, Farrell D, Mattoussi H, Dawson PE. Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots. Journal of the American Chemical Society 2010, 132 29), 10027-33. doi:10.1021/ja910988d
Van de Vijver P, Suylen D, Dirksen A, Dawson PE, Hackeng TM. N(epsilon)-(thiaprolyl)-lysine as a handle for site-specific protein conjugation. Biopolymers 2010, 94(4), 465-74. doi:10.1002/bip.21485
Stewart MH, Susumu K, Mei BC, Medintz IL, Delehanty JB, Blanco-Canosa JB, Dawson PE, Mattoussi HJ. Multidentate poly(ethylene glycol) ligands provide colloidial stability to semicondcutor and metallic nanocrystals in extreme conditions. Journal of the American Chemical Society 2010, 32(28), 9804-13. doi:10.1021/ja102898d
Delehanty JB, Bradburne CE, Boeneman K, Susumu K, Farrell D, Mei BC, Blanco-Canosa JB, Dawson G, Dawson PE, Mattoussi H, Medintz IL. Delivering quantum dot-peptide bioconjugates to the cellular cystosol: escaping from the endolysosomal system. Integrative Biology (Cambridge) 2010, 2(5-6), 265-77. doi:10.1039/c0ib00002g
Oh E, Susumu K, Blanco-Canosa JB, Medintz IL, Dawson PE, Mattoussi H. Preparation of stable maleimide-functionalized au nanoparticles and their use in counting surface ligands. Small 2010, 6(12), 1273-78. doi:10.1002/smll.201000279
Erlich LA, Kumar KS, Haj-Yahya M, Dawson PE, Brik A. N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester. Organic and Biomolecular Chemistry 2010, 8(10), 2392-96. doi:10.1039/c000332h
Brunel FM, Lewis JD, Destito G, Steinmetz NF, Manchester M, Stuhlmann H, Dawson PE. A hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Letters 2010, 10(3), 1093-97. doi:10.1021/nl1002526
Tiefenbrunn TK, Dawson PE. Alternative chemistries for the synthesis of thrombospondin-1 type 1 repeats. Biopolymers 2010, 94(4), 405-13. doi:10.1002/bip.21486
Dawson G, Schroeder C, Dawson PE. Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease, Biochemical and Biophysical Research Communications 2010, 395(1), 66-9. doi:10.1016/j.bbrc.2010.03.137
Dirksen A, Yegneswaran S, Dawson PE. Bisaryl hydrazones as exchangeable biocompatible linkers. Angew Chem Int Ed Engl. 2010, 49(11), 2023-2. doi:10.1002/anie.200906756
Prasuhn D, Deschamps JR, Susumu K, Stewart MH, Boeneman K, Blanco-Canosa JB, Dawson PE, Medintz IL. Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental results.  Small 2010, 6(4), 555-64. doi:10.1002/smll.200901845
Prasuhn D, Blanco-Canosa JB, Vora G, Delehanty J, Susumu K, Mei BC, Dawson PE, Medintz IL. Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dots.  ACS Nano 2010, 4(1), 267-78. doi:10.1021/nn901393v
Sapsford KE, Blanco-Canosa JB, Dawson PE, Medintz IL. Detection of HIV-1 specific monoclonal antibodies using enhancement of dye-labeled antigenic peptides. Bioconjugate Chemistry  2010, 21(2), 393-8. doi:10.1021/bc9003712
Tiefenbrunn TK, Dawson PE. Chemoselective Ligation Techniques: Modern Applications of Time-Honored ChemistryBiopolymers: Peptide Science 2010, 94 (1), 95-106. doi: 10.1002/bip.21337
Shekhter T, Metanis N, Dawson PE, Keinan E. A residue outside the active site CXXC motif regulates the catalytic efficency of Glutaredoxin 3. Molecular Biosystems 2010, 6(1), 241-48. doi:10.1039/b912753d
Vanacore R, Ham AJL, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG. A sulfilimine bond identified in collagen IV. Science 2009, 325(5945), 1230-34. doi:10.1126/science.1176811
Tiefenbrunn TK, Dawson PE. Chemical synthesis and biotinylation of the thrombospondin domain TSR2. Protein Science 2009, 18(5), 970-79. doi:10.1002/pro.107
Thielges MC, Zimmermann J, Dawson PE, Romesberg FE. The determinants of stability and folding in evolutionarily diverged cytochromes c. Journal of Molecular Biology 2009, 388(1), 159-67. doi:10.1016/j.jmb.2009.02.059
Pejchal R, Gach JS, Brunel FM, Cardoso RM, Stanfield RL, Dawson PE, Burton DR, Zwick MB, Wilson IA. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. Journal of Virology 2009, 83(17), 8451-62. doi:10.1128/jvi.00685-09
Medintz IL, Farrell D, Susumu K, Trammell SA, Deschamps JR, Brunel FM, Dawson PE, Mattoussi H. Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes. Analytical Chemistry 2009, 81(12), 4831-39. doi:10.1021/ac900412j
Kraut DA, Churchill MJ, Dawson PE, Herschlag D. Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis. ACS Chemical Biology 2009, 4(4), 269-73. doi:10.1021/cb900016q
Zeng Y, Ramya TNC, Dirksen A, Dawson PE, Paulson JC. High-efficiency labeling of sialylated glycoproteins on living cellsNature Methods 2009, 6(3), 207-09. doi:10.1038/nmeth.1305
Cremeens ME, Zimmermann J, Yu W, Dawson PE, Romesberg FE. Direct observation of structural heterogeneity in a beta-sheet. Journal of the American Chemical Society 2009, 131(16), 5726-27. doi:10.1021/ja900505e
Yegneswaran S, Hackeng TM, Dawson PE, Griffin JH. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. Journal of Biological Chemistry 2008, 283(48), 33046-52. doi:10.1074/jbc.M806527200
Yamamoto N, Tanabe Y, Okamoto R, Dawson PE, Kajihara Y. Chemical synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide under the Boc and Fmoc synthetic strategiesJournal of the American Chemical Society 2008, 130(2), 501-10. doi:10.1021/ja072543f
Weinkam P, Zimmermann J, Sagle LB, Matsuda S, Dawson PE, Wolynes PG, Romesberg FE. Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes. Biochemistry 2008, 47(51), 13470-80. doi:10.1021/bi801223n
Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T, Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman DD, Burton DR, Zwick MB. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. Virology 2008, 377(1), 170-83. doi:10.1016/j.virol.2008.04.005
Medintz IL, Pons T, Trammell SA, Grimes AF, English DS, Blanco-Canosa JB, Dawson PE, Mattoussi H. Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridge. Journal of the American Chemical Society 2008, 130(49), 16745-56. doi:10.1021/ja805456x
Burlina F, Dixson DD, Doyle RP, Chassaing G, Boddy CN, Dawson P, Offer J. Orthogonal ligation: A three piece assembly of a PNA-peptide-PNA conjugate. Chemical Communications 2008, (24), 2785-87. doi:10.1039/b801242c
Medintz IL, Pons T, Delehanty JB, Susumu K, Brunel FM, Dawson PE, Mattoussi H. Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides. Bioconjugate Chemistry 2008, 19(9), 1785-95. doi:10.1021/bc800089r
Dirksen A, Dawson PE. Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling. Bioconjugate Chemistry 2008, 19(12), 2543-48. doi:10.1021/bc800310p
Blanco-Canosa JB, Dawson PE. An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation. Angew Chem Int Ed Engl. 2008, 47(36), 6851-55. doi:10.1002/anie.200705471
Dirksen A, Dawson PE. Expanding the scope of chemoselective peptide ligations in chemical biology. Current Opinion in Chemical Biology 200812 (6), 760-766. doi: 10.1016/j.cbpa.2008.10.009
Yegneswaran S, Tiefenbrunn TK, Fernandez JA, Dawson PE. Manipulation of thrombin exosite I, by ligand-directed covalent modification. Journal of Thrombosis and Haemostasis 2007, 5(10), 2062-69. doi:10.1111/j.1538-7836.2007.02712.x
Xu Y, Hixon MS, Dawson PE, Janda KD. Development of a FRET assay for monitoring of HIV gp41 core disruption. Journal of Organic Chemistry 2007, 72(18), 6700-07. doi:10.1021/jo070836l
Sapsford KE, Pons T, Medintz IL, Higashiya S, Brunel FM, Dawson PE, Mattoussi H. Kinetics of metal-affinity driven self-assembly between proteins or peptides and CdSe-ZnS quantum dots. Journal of Physical Chemistry C 2007, 111(31), 11528-38. doi:10.1021/jp073550t
Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RMF, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB. An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10. Journal of Virology 2007, 81(8), 4033-43. doi:10.1128/jvi.02588-06
Clapp AR, Pons T, Medintz IL, Delehanty JB, Melinger JS, Tiefenbrunn T, Dawson PE, Fisher BR, O’Rourke B, Mattoussi H. Two-photon excitation of quantum-dot-based fluorescence resonance energy transfer and its applications. Advanced Materials 2007, 19(15), 1921-26. doi:10.1002/adma.200602036
Cardoso RMF, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson IA. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10Journal of Molecular Biology 2007, 365(5), 1533-44. doi:10.1016/j.jmb.2006.10.088
Blankenship JW, Dawson PE. Threading a peptide through a peptide: Protein loops, rotaxanes, and knotsProtein Science 2007, 16(7), 1249-56. doi:10.1110/ps.062673207
Dawson PE. Chemical Synthesis of Proteins and Large Bioconjugates. In: Chemical Biology Volume 2, Wiley-VCH. 2007.
Yamamoto N, Takayanagi A, Sakakibara T, Dawson PE, Kajihara Y. Highly efficient synthesis of sialylglycopeptides overcoming unexpected aspartimide formation during activation of Fmoc-Asn(undecadisialyloligosaccharide)-OH. Tetrahedron Letters 2006, 47(8), 1341-46. doi:10.1016/j.tetlet.2005.12.064
Sagle LB, Zimmermann J, Matsuda S, Dawson PE, Romesberg FE. Redox-coupled dynamics and folding in cytochrome c. Journal of the American Chemical Society 2006, 128(24), 7909-15. doi:10.1021/ja060851s
Sagle LB, Zimmermann J, Dawson PE, Romesberg FE. Direct and high resolution characterization of cytochrome c equilibrium folding. Journal of the American Chemical Society 2006, 128(44), 14232-33. doi:10.1021/ja065179d
Metanis N, Keinan E, Dawson PE. Synthetic seleno-glutaredoxin 3 analogues are highly reducing oxidoreductases with enhanced catalytic efficiency. Journal of the American Chemical Society 2006, 128(51), 16684-91. doi:10.1021/ja0661414
Medintz IL, Clapp AR, Brunel FM, Tiefenbrunn T, Uyeda HT, Chang EL, Deschamps JR, Dawson PE, Mattoussi H. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates. Nature Materials 2006, 5(7), 581-89. doi:10.1038/nmat1676
Dirksen A, Hackeng TM, Dawson PE. Nucleophilic catalysis of oxime ligation. Angew Chem Int Ed Engl. 2006, 45(45), 7581-84. doi:10.1002/anie.200602877
Dirksen A, Dirksen S, Hackeng TM, Dawson PE. Nucleophilic catalysis of hydrazone formation and transimination: Implications for dynamic covalent chemistry. Journal of the American Chemical Society 2006, 128(49), 15602-03. doi:10.1021/ja067189k
Delehanty JB, Medintz IL, Pons T, Brunel FM, Dawson PE, Mattoussi H. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjugate Chemistry 2006, 17(4), 920-27. doi:10.1021/bc060044i
Cremeens ME, Fujisaki H, Zhang Y, Zimmermann J, Sagle LB, Matsuda S, Dawson PE, Straub JE, Romesberg FE. Efforts toward developing direct probes of protein dynamics. Journal of the American Chemical Society 2006, 128(18), 6028-29. doi:10.1021/ja061328g
Brunel FM, Zwick MB, Cardoso RMF, Nelson JD, Wilson IA, Burton DR, Dawson PE. Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. Journal of Virology 2006, 80(4), 1680-87. doi:10.1128/jvi.80.4.1680-1687.2006
Neuman BW, Stein DA, Kroeker AD, Churchill MJ, Kim AM, Kuhn P, Dawson PE, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomersJournal of Virology 2005, 79(15), 9665-76. doi:10.1128/jvi.79.15.9665-9676.2005
Metanis N, Keinan E, Dawson PE. A designed synthetic analogue of 4-OT is specific for a non-natural substrate. Journal of the American Chemical Society 2005, 127(16), 5862-68. doi:10.1021/ja050110b
McNulty JC, Jackson PJ, Thompson DA, Chai BX, Gantz I, Barsh GS, Dawson PE, Millhauser GL. Structures of the agouti signaling protein. Journal of Molecular Biology 2005, 346(4), 1059-70. doi:10.1016/j.jmb.2004.12.030
Brunel FM, Dawson PE. Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41. Chemical Communications 2005,  28(20), 2552-54. doi:10.1039/b419015g
Beltran AC, Dawson PE, Gottesfeld JM. Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains. Chembiochem 2005, 6(1), 104-13. doi:10.1002/cbic.200400184
Sagle LB, Zimmermann J, Dawson PE, Romesberg FE. A high-resolution probe of protein folding. Journal of the American Chemical Society 2004, 126(11), 3384-85. doi:10.1021/ja049890z
Metanis N, Brik A, Dawson PE, Keinan E. Electrostatic interactions dominate the catalytic contribution of Arg39 in 4-oxalocrotonate tautomerase. Journal of the American Chemical Society 2004, 126(40), 12726-27. doi:10.1021/ja0463841
Marinzi C, Offer J, Longhi R, Dawson PE. An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications. Bioorganic & Medicinal Chemistry 2004, 12(10), 2749-57. doi:10.1016/j.bmc.2004.02.039
Kamikubo Y, De Guzman R, Kroon G, Curriden S, Neels JG, Churchill MJ, Dawson PE, Oldziej S, Jagielska A, Scheraga HA, Loskutoff DJ, Dyson HJ. Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin. Biochemistry 2004, 43(21), 6519-34. doi:10.1021/bi049647c
Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW. Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics. Nature 2004, 430(6995), 101-05. doi:10.1038/nature02611
Deechongkit S, Dawson PE, Kelly JW. Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbationsJournal of the American Chemical Society 2004, 126(51), 16762-71. doi:10.1021/ja045934s
Dawson PE, Leumann CJ. Challenge complex biological function with smart chemistry – Editorial overview. Current Opinion in Chemical Biology 20048 (6), 567-569. doi: 10.1016/j.cbpa.2004.10.006
Zwick MB, Parren PWHI, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120Journal of Virology 2003, 77(10), 5863-76. doi:10.1128/jvi.77.10.5863-5876.2003
Blankenship JW, Dawson PE. Thermodynamics of a designed protein catenane. Journal of Molecular Biology 2003, 327(2), 537-48. doi:10.1016/s0022-2836(03)00115-3
Bayro MJ, Mukhopadhyay J, Swapna GVT, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH. Structure of antibacterial peptide microcin J25: A 21-residue lariat protoknot. Journal of the American Chemical Society 2003, 125(41), 12382-83. doi:10.1021/ja036677e
Dawson PE, Offer J. Protein Synthesis on Solid Support. In: Science for Synthesis, Houben Weyl, 2003.
Yegneswaran S, Fernandez JA, Griffin JH, Dawson PE. Factor Va increases the affinity of factor Xa for prothrombin: A binding study using a novel photoactivable thiol-specific fluorescent probe. Chemistry & Biology 2002, 9(4), 485-94. doi:10.1016/s1074-5521(02)00132-1
Offer J, Boddy CNC, Dawson PE. Extending synthetic access to proteins with a removable acyl transfer auxiliary. Journal of the American Chemical Society 2002, 124(17), 4642-46. doi:10.1021/ja016731w
Marx PF, Dawson PE, Bouma BN, Meijers JCM. Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor. Biochemistry 2002, 41(21), 6688-96. doi:10.1021/bi015982e
Dawson G, Dawson SA, Marinzi C, Dawson PE. Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell lineCancer Letters 2002, 187(1-2), 163-68. doi:10.1016/s0304-3835(02)00403-2
Brik A, Dawson PE, Keinan E. The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant. Bioorganic & Medicinal Chemistry 2002, 10(12), 3891-97. doi:10.1016/s0968-0896(02)00385-1
Brik A, D’Souza LJ, Keinan E, Grynszpan F, Dawson PE. Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism. Chembiochem 2002, 3(9), 845-51. doi:10.1002/1439-7633(20020902)3:9<845::aid-cbic845>3.0.co;2-2
Blankenship JW, Balambika R, Dawson PE. Probing backbone hydrogen bonds in the hydrophobic core of GCN4. Biochemistry 2002, 41(52), 15676-84. doi:10.1021/bi026862p
Dawson PE. Ligation Methods. In: Science of Synthesis, Houben Weyl. 2002.
Yan LZ, Dawson PE. Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization. Journal of the American Chemical Society 2001, 123(4), 526-33. doi:10.1021/ja003265m
Yan LZ, Dawson PE. Design and synthesis of a protein catenane. Angew Chem Int Ed Engl. 2001, 40(19), 3625-31. doi:10.1002/1521-3773(20011001)40:19<3625::aid-anie3625>3.0.co;2-q
Marinzi C, Bark SJ, Offer J, Dawson PE. A new scaffold for amide ligation. Bioorganic & Medicinal Chemistry 2001, 9(9), 2323-28. doi:10.1016/s0968-0896(01)00136-5
Pelletier AJ, van der Laan LJW, Hildbrand P, Siani MA, Thompson DA, Dawson PE, Torbett BE, Salomon DR. Presentation of chemokine SDF-1 alpha by fibronectin mediates directed migration of T cells. Blood 2000, 96(8), 2682-90. PMID:11023498
Offer J, Dawson PE. N-alpha-2-mercaptobenzylamine-assisted chemical ligation. Organic Letters 2000, 2(1), 23-26. doi:10.1021/ol991184t
Marx PF, Hackeng TM, Dawson PE, Griffin JH, Meijers JCM, Bouma BN. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. Journal of Biological Chemistry 2000, 275(17), 12410-15. doi:10.1074/jbc.275.17.12410
King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. Journal of Biological Chemistry 2000, 275(24), 18108-13. doi:10.1074/jbc.M909663199
Hackeng TM, Fernandez JA, Dawson PE, Kent SBH, Griffin JH. Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S. Proceedings of the National Academy of Sciences 2000, 97(26), 14074-78. doi:10.1073/pnas.260239797
Deniz AA, Laurence TA, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson PE, Schultz PG, Weiss S. Single-molecule protein folding: Diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2. Proceedings of the National Academy of Sciences 2000, 97(10), 5179-84. doi:10.1073/pnas.090104997
Cho SG, Dawson PE, Dawson G. In vitro depalmitoylation of neurospecific peptides: Implication for infantile neuronal ceroid lipofuscinosis. Journal of Neuroscience Research 2000, 59(1), 32-38. doi:10.1002/(sici)1097-4547(20000101)59:1<32::aid-jnr5>3.0.co;2-a
Cho SG, Dawson PE, Dawson G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells. Journal of Neuroscience Research 2000, 62(2), 234-40. doi:10.1002/1097-4547(20001015)62:2<234::aid-jnr8>3.0.co;2-8
Brik A, Keinan E, Dawson PE. Protein synthesis by solid-phase chemical ligation using a safety catch linker. Journal of Organic Chemistry 2000, 65(12), 3829-35. doi:10.1021/jo000346s
Dawson PE, Kent SBH. Synthesis of native proteins by chemical ligation. Annual Review of Biochemistry 200069, 923-960. doi: 10.1146/annurev.biochem.69.1.923
Beligere GS, Dawson PE. Design, synthesis, and characterization of 4-ester CI2, a model for backbone hydrogen bonding in protein alpha-helices. Journal of the American Chemical Society 2000, 122(49), 12079-82. doi:10.1021/ja001648e
Beck ZQ, Hervio L, Dawson PE, Elder JH, Madison EL. Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development. Virology 2000, 274(2), 391-01. doi:10.1006/viro.2000.0420
Hackeng TM, Griffin JH, Dawson PE. Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology. Proceedings of the National Academy of Sciences 1999, 96(18), 10068-73. doi:10.1073/pnas.96.18.10068
Coombs GS, Rao MS, Olson AJ, Dawson PE, Madison EL. Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains. Journal of Biological Chemistry 1999, 274(34), 24074-79. doi:10.1074/jbc.274.34.24074
Beligere GS, Dawson PE. Conformationally assisted protein ligation using C-terminal thioester peptides. Journal of the American Chemical Society 1999, 121(26), 6332-33. doi:10.1021/ja9907919
Beligere GS, Dawson PE. Synthesis of a three zinc finger protein, Zif268, by native chemical ligation. Biopolymers 1999, 51(5), 363-69. doi:10.1002/(sici)1097-0282(1999)51:5<363::aid-bip6>3.3.co;2-f
Hackeng TM, Dawson PE, Kent SBH, Griffin JH. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers 1998, 46(2), 53-63. doi:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6
Muir TW, Dawson PE, Kent SBH. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution. Methods in Enzymology 1997289, 266-298. doi: 10.1016/S0076-6879(97)89052-0
Muir TW, Dawson PE, Fitzgerald MC, Kent SBH. Protein signature analysis: A practical new approach for studying structure-activity relationships in peptides and proteins. Methods in Enzymology 1997289, 545-564. doi: 10.1016/S0076-6879(97)89063-5
Dawson PE. Synthesis of chemokines by native chemical ligation. Methods in Enzymology 1997287, 34-45. doi: 10.1016/S0076-6879(97)87005-X
Hackeng TM, Mounier CM, Bon C, Dawson PE, Griffin JH, Kent SBH. Total chemical synthesis of enzymatically active human type II secretory phospholipase A(2). Proceedings of the National Academy of Sciences 1997, 94(15), 7845-50. doi:10.1073/pnas.94.15.7845
Dawson PE, Fitzgerald MC, Muir TW, Kent SBH. Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues. Journal of the American Chemical Society 1997, 119(34), 7917-27. doi:10.1021/ja963122t
Dawson PE, Churchill MJ, Ghadiri MR, Kent SBH. Modulation of reactivity in native chemical ligation through the use of thiol additivesJournal of the American Chemical Society 1997, 119(19), 4325-29. doi:10.1021/ja962656r
Muir TW, Dawson PE, Fitzgerald MC, Kent SBH. Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chemistry & Biology 1996, 3(10), 817-25. doi:10.1016/s1074-5521(96)90067-8
Bruick RK, Dawson PE, Kent SBH, Usman N, Joyce GF. Template-directed ligation of peptides to oligonucleotides. Chemistry & Biology 1996, 3(1), 49-56. doi:10.1016/s1074-5521(96)90084-8
Dawson PE, Muir TW, Clark-Lewis I, Kent SBH. Synthesis of Proteins by Native Chemical Ligation. Science 1994, 266 (5186), 776-779. doi:10.1126/science.7973629
Dawson PE, Kent SBH. Convenient total synthesis of a 4-Helix tasp molecule by chemoselective ligation. Journal of the American Chemical Society 1993, 115(16), 7263-66. doi:10.1021/ja00069a027